EPHB3

EPH receptor B3

Ensembl:
ENSG00000182580
UniProt:
P54753
OMIM:
601839
Synonyms:
ETK2, HEK2, TYRO6

Cilia effects upon perturbation of EPHB3

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.24) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Axon guidance & growth

Function

EFNB1, EFNB2, and EPHA4 proteins colocalize or partially colocalize with Arl13b (PMID: 40623838).

Model organism evidence

Mus musculus (2 references)

Loss of primary cilia promotes EphA2-mediated endothelial-to-mesenchymal transition in the ovarian tumor microenvironment.

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.

PMIDs: 40397771, 38187761