ESPL1

extra spindle pole bodies like 1, separase

Ensembl:
ENSG00000135476
UniProt:
Q14674
OMIM:
604143
Synonyms:
ESP1, KIAA0165, SEPA

Cilia effects upon perturbation of ESPL1

Cilia number / % ciliated:
Unknown
Loss-of-function effect:
Supernumerary cilia
Overexpression effect:
Unknown

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.55) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Basu et al. 2023 (siRNA) [siRNA]: Left-Right Asymmetry Defect (Z2MCilia=7.45, increased) PMID:37771269
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

Loss of ESPL1 gene cause supernumerary cilia(PMID: 37771269).