EVI5L

ecotropic viral integration site 5 like

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000142459
UniProt:: Q96CN4

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:27956704

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Viral interactions

Function

Reducing Evi5l expression in MEFs lacking Tgifs resulted in a partial restoration of cilium numbers and in the transcriptional response to activation of the Shh pathway.

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