EXOC3

exocyst complex component 3

Ensembl:: ENSG00000180104
UniProt:: O60645
OMIM:: 608186
Synonyms:: SEC6, SEC6L1

Cilia effects upon perturbation of EXOC3

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.48) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: increased lean body mass, decreased total body fat amount, decreased fasting circulating glucose level

Subcellular localization

cilia

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Metabolism
Ciliary membrane

Function

Also known as SEC6. Inhibition of ciliary shedding, blocks deciliation-associated down-regulation of claudin-2 and gp135 (PMID:19005211). Sec6/8 complex cooperates with cooperate with syntaxin 3 and S P-25, ceing a candidate effector for Rab8 at the rhodopsin transport carriers (RTC) docking site (19454479)

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