EXOC5

exocyst complex component 5

Ensembl:
ENSG00000070367
UniProt:
O00471
OMIM:
604469
Synonyms:
SEC10, SEC10L1, SEC10P

Cilia effects upon perturbation of EXOC5

Loss-of-function effect:
Shorter cilia
Overexpression effect:
Longer cilia

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.24) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • Ciliary membrane

Function

Also known as SEC10. Central and particularly important exocyst component required for exocyst formation and function. Regulation of primary ciliogenesis and cystogenesis through interactions with Par3 (19297529, 30824539). Linker for other exocyst components, and interacts with polycystin-2, IFT20 and IFT88. Dysfunction may contribute to ciliopathies including autosomal domi nt polycystic kidney disease ADPKD (21490950).

Model organism evidence

Mus musculus (2 references)

High water intake induces primary cilium elongation in renal tubular cells.

The role of the exocyst in renal ciliogenesis, cystogenesis, tubulogenesis, and development.

PMIDs: 37933114, 31284362