EXOC6B

exocyst complex component 6B

Ensembl:: ENSG00000144036
UniProt:: Q9Y2D4
OMIM:: 607880
Synonyms:: KIAA0919, SEC15B, SEC15L2

Cilia effects upon perturbation of EXOC6B

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (2 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.18) PMID:41160700

Phenotypes

Mouse phenotype:: decreased circulating glucose level, preweaning lethality, complete penetrance

Subcellular localization

cilia

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation

Function

Also called sec15b. Interacts with Rabin8 which is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15. Depletion decreases the number of ciliated cells.

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