EXOC7

exocyst complex component 7

Ensembl:
ENSG00000182473
UniProt:
Q9UPT5
OMIM:
608163
Synonyms:
BLOM4, EXO70, EXO70P, KIAA1067, YJL085W

Cilia effects upon perturbation of EXOC7

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=2.09) PMID:20393562

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, abnormal locomotor behavior
Human ciliopathy phenotype:
neurodevelopmental disorder with seizures and brain atrophy

Subcellular localization

basal body, centrosome, microtubules

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • Ciliary membrane

Function

EXOC7 have interactions of with BBS proteins and expression did not overlap with g-tubulin but was detected in close vicinity to the microtubule-organizing center (MTOC) (18000879).

Model organism evidence

Drosophila (1 reference)

Its roles, however, extend beyond exocytosis and include organelle biogenesis, ciliogenesis, cell migration, and cell growth.

PMIDs: 30209205