EZH2

enhancer of zeste 2 polycomb repressive complex 2 subunit

Ensembl:
ENSG00000106462
UniProt:
Q15910
OMIM:
601573
Synonyms:
ENX-1, EZH1, KMT6, KMT6A

Cilia effects upon perturbation of EZH2

Loss-of-function effect:
Longer cilia
Overexpression effect:
Decreased

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.09) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.51) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.28, ciliated=55.1%) PMID:26595381

Subcellular localization

basal body, cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Neurogenesis & migration
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

Methyltransferase unit of PRC2. EZH2 suppresses genes functio lly connected to the primary cilium, promoting loss of primay cilia, inhibition induces primary cilium formation in most melanoma cell. Loss of cilia