FAM161B

FAM161 centrosomal protein B

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000156050
UniProt:: Q96MY7
Synonyms:: C14ORF44, FLJ31697

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: enlarged spleen, abnormal thymus morphology, enlarged thymus, abnormal spleen morphology, abnormal skeletal muscle morphology, enlarged lymph nodes, abnormal lymph node morphology

Subcellular localization

basal body, cilia

References: PMID:22791751, PMID:22940612

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

The retinitis pigmentosa 28 protein FAM161A is ciliary protein involved in intermolecular protein interaction and microtubule association(22791751) and associated with retinitis pigmentosa, is a component of the cilia-basal body complex and interacts with proteins involved in ciliopathies(22940612).

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