FAM161B

FAM161 centrosomal protein B

Ensembl:
ENSG00000156050
UniProt:
Q96MY7
Synonyms:
C14ORF44, FLJ31697

Cilia effects upon perturbation of FAM161B

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
enlarged spleen, abnormal thymus morphology, enlarged thymus, abnormal spleen morphology, abnormal skeletal muscle morphology, enlarged lymph nodes, abnormal lymph node morphology
Mouse ciliopathy phenotype:
abnormal heart morphology, enlarged heart

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

The retinitis pigmentosa 28 protein FAM161A is ciliary protein involved in intermolecular protein interaction and microtubule association(22791751) and associated with retinitis pigmentosa, is a component of the cilia-basal body complex and interacts with proteins involved in ciliopathies(22940612).

Model organism evidence

Mus musculus (3 references)

Fly Fam161 is an essential centriole and cilium transition zone protein with unique and diverse cell type-specific localizations.

FAM161A, associated with retinitis pigmentosa, is a component of the cilia-basal body complex and interacts with proteins involved in ciliopathies.

PMIDs: 39255847, 22940612, 22791751

C. elegans (1 reference)

Using whole-organism RNA-Seq libraries, we discovered a signature expression profile highly enriched for transcripts of known ciliary proteins, including FAM-161 (FAM161A orthologue), CCDC-104 (CCDC104), and RPI-1 (RP1/RP1L1), which we confirm are cilium-localised in worms.

PMIDs: 27930654