FBF1

Fas binding factor 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000188878
UniProt:
Q8TES7
OMIM:
616807
Synonyms:
ALB, FBF-1, FLJ00103, KIAA1863

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.85) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.51) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.95, ciliated=15.0%) PMID:26595381

Ciliopathy associations

  • Hydrolethalus Syndrome

References: PMID:38963098

Subcellular localization

centrosome, cilia, transition zone, basal body

References: PMID:41005307, PMID:24231678, PMID:30318703

Functional category

  • Ciliary assembly/disassembly

Function

Transition fiber protein required for ciliogenesis and the ciliary import of assembled intraflagellar transport particles at the cilia base (24231678). Functions in centriole duplication by recruiting