FBF1

Fas binding factor 1

Ensembl:
ENSG00000188878
UniProt:
Q8TES7
OMIM:
616807
Synonyms:
ALB, FBF-1, FLJ00103, KIAA1863

Cilia effects upon perturbation of FBF1

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.85) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.51) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.95, ciliated=15.0%) PMID:26595381

Ciliopathy associations

  • Hydrolethalus Syndrome

Subcellular localization

centrosome, cilia

Functional category

  • Ciliary assembly/disassembly

Function

Transition fiber protein required for ciliogenesis and the ciliary import of assembled intraflagellar transport particles at the cilia base (24231678). Functions in centriole duplication by recruiting

Model organism evidence

C. elegans (2 references)

Primary cilia are compartmentalised from the rest of the cell by a ciliary gate comprising transition fibres and a transition zone.

TALP-3 and ANKR-26 form a complex with key gating component DYF-19, the homolog of FBF1. Co-depletion of TALP-3 and ANKR-26 specifically impairs the recruitment of DYF-19 to transition fibers, implicating FBF1/DYF-19 as a key ciliary gate component.

PMIDs: 34357392, 32366837

Drosophila (1 reference)

Primary cilia are compartmentalised from the rest of the cell by a ciliary gate comprising transition fibres and a transition zone.

PMIDs: 34357392