FBXL13

F-box and leucine rich repeat protein 13

Ensembl:: ENSG00000161040
UniProt:: Q8NEE6
OMIM:: 609080
Synonyms:: CFAP169, DRC6, FBL13, MGC21636

Cilia effects upon perturbation of FBXL13

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

flagella

Function

Mutated Fbxl13 and Drc7, two genes with strong expression in mouse testis and which have been shown to be important for flagellum formation and regulation in other systems (31961863).

Model organism evidence

Mus musculus (1 reference)

Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice.

PMIDs: 31961863

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