FBXO38

Cilia effects upon perturbation of FBXO38

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-9.15) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.13, ciliated=54.0%) PMID:26595381

Phenotypes

Mouse phenotype:

decreased bone mineral density, decreased locomotor activity, increased mean platelet volume, increased basophil cell number, increased lymphocyte cell number, increased red blood cell distribution width, increased leukocyte cell number, decreased body length, small liver, increased heart rate

Mouse ciliopathy phenotype:

male infertility, increased circulating aspartate transamise level, increased circulating alanine transamise level, female infertility

Subcellular localization

basal body, cilia, nucleus, transition zone

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• T cell biology
• Cell migration & adhesion
• Transition zone

Function

FBXO38 has localized in ciliary tip, basal body, transition zone.