FBXW11

F-box and WD repeat domain containing 11

Ensembl:: ENSG00000072803
UniProt:: Q9UKB1
OMIM:: 605651
Synonyms:: BTRC2, BTRCP2, FBW11, FBW1B, FBXW1B

Cilia effects upon perturbation of FBXW11

Ciliogenesis screen results (5 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.17) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=10, lfc=1.61) PMID:30270045

Subcellular localization

centriolar satellites, nucleoplasm, plasma membrane, vesicles

Function

The collection of regulators has diverse distributions throughout the cell with Bfar, Cop1, Cul9, Fancg, Skp1a, Uba3, Ube2l3, and Wwp1 showing weak localization to cilia. In addition, Sytl4 localized to the ciliary pocket at the base of the cilium, and Fbxw11 localized to centriolar satellites . Positive regulator of Hedgehog signaling(PMID: 34161574).

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