FFAR4

free fatty acid receptor 4

Ensembl:
ENSG00000186188
UniProt:
Q5NUL3
OMIM:
609044
Synonyms:
GPR120, GPR129, O3FAR1, PGR4

Cilia effects upon perturbation of FFAR4

Ciliogenesis screen results (1 screen)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Metabolism
  • T cell biology
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane

Function

Ciliary GPCRs are critical for adipogenesis, and FFAR4/GPR120 localizes to cilia and 蠅-3 fatty acids activate ciliary FFAR4 and trigger adipogenesis via ciliary cAMP(31761534).

Model organism evidence

Mus musculus (1 reference)

Transport of GPCRs to primary cilia requires TULP3, whose knockdown in primary human and mouse islets relocalized ciliary FFAR4 and PTGER4 and impaired regulated glucagon or insulin secretion, without affecting ciliary structure.

PMIDs: 34385262