FFAR4

free fatty acid receptor 4

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000186188
UniProt:
Q5NUL3
OMIM:
609044
Synonyms:
GPR120, GPR129, O3FAR1, PGR4

Ciliogenesis screen results (1 screens)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia, basal body

References: PMID:41005307, PMID:31761534

Functional category

  • Ciliary assembly/disassembly
  • Metabolism
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane

Function

Ciliary GPCRs are critical for adipogenesis, and FFAR4/GPR120 localizes to cilia and ω-3 fatty acids activate ciliary FFAR4 and trigger adipogenesis via ciliary cAMP(31761534).