FGF1

fibroblast growth factor 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000113578
UniProt:
P05230
OMIM:
131220
Synonyms:
AFGF, ECGF, ECGF-BETA, ECGFA, ECGFB, FGF-ALPHA, FGFA, GLIO703, HBGF1

Cilia effects upon perturbation of FGF1

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.18) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=2.69) PMID:20393562

Subcellular localization

basal body, cilia, cytosol, nucleus

References: PMID:33772852

Functional category

  • Ciliary assembly/disassembly
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Cytoplasmic and nuclear FGF1 immunoreactivity was detected in the epithelium lining the infundibulum, ampulla and isthmus of the oviduct. Immunoreactivity was much stronger in the basal bodies of the cilia on the epithelium lining the infundibulum and ampulla (33772852).