FGF10

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

decreased thigmotaxis, abnormal behavior, cornea opacity, decreased lean body mass, decreased grip strength, increased total body fat amount, increased circulating cholesterol level, impaired pupillary reflex, rrow eye opening, decreased leukocyte cell number, abnormal craniofacial morphology, abnormal cornea morphology, increased circulating hdl cholesterol level, decreased locomotor activity, preweaning lethality, complete penetrance

Subcellular localization

cilia, nucleus

References: PMID:40257378

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Cell migration & adhesion
• Signaling (Hedgehog, GPCRs, ion channels)
• Cardiac & muscle development
• Transcription regulation

Function

Upon FGF10 stimulation, the activated FGFR2 initiates the downstream signaling by phosphorylation (p) of FRS2, MEK1, ERK1/2, and p38(MAPK14 ) within the cilium, which results in transcription of the target genes(40257378).