FGF2

fibroblast growth factor 2

Ensembl:
ENSG00000138685
UniProt:
P09038
OMIM:
134920
Synonyms:
FGFB

Cilia effects upon perturbation of FGF2

Overexpression effect:
Increased

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.07) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
limb grasping, increased circulating serum albumin level, increased circulating total protein level
Mouse ciliopathy phenotype:
abnormal reti morphology

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Neurogenesis & migration
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • ECM & connective tissue
  • Transcription regulation

Function

FGF2 gene stimulates cilia elongation via FGFR-ICK signaling in fibroblasts, requires ICK for effect(PMID: 30782830).