FGF23

fibroblast growth factor 23

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000118972
UniProt:: Q9GZV9
OMIM:: 605380

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: abnormal anxiety-related response, decreased circulating chloride level, increased anxiety-related response, increased blood urea nitrogen level, abnormal spleen morphology, decreased startle reflex, decreased exploration in new environment, increased freezing behavior, decreased locomotor activity, abnormal startle reflex, decreased circulating iron level, increased lung elastance

Subcellular localization

basal body

References: PMID:25613900, PMID:35818799

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

Disruptions in the FGF23–PTH axis resulting in reduced calcium uptake in the developing mandible and potential treatment for ciliopathic micrognathia (35818799).FGF23 localized to basal body (25613900)

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