FGF23

Cilia effects upon perturbation of FGF23

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

abnormal anxiety-related response, decreased circulating chloride level, increased anxiety-related response, increased blood urea nitrogen level, abnormal spleen morphology, decreased startle reflex, decreased exploration in new environment, increased freezing behavior, decreased locomotor activity, abnormal startle reflex, decreased circulating iron level, increased lung elastance

Mouse ciliopathy phenotype:

abnormal reti vasculature morphology

Subcellular localization

basal body

Functional category

• Ciliary assembly/disassembly
• Signaling (Hedgehog, GPCRs, ion channels)

Function

Disruptions in the FGF23–PTH axis resulting in reduced calcium uptake in the developing mandible and potential treatment for ciliopathic microg thia (35818799).FGF23 localized to basal body (25613900)