FGF4

fibroblast growth factor 4

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000075388
UniProt:
P08620
OMIM:
164980
Synonyms:
HBGF-4, HST, HST-1, HSTF1, K-FGF, KFGF

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-13.10) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=422, lfc=0.56) PMID:30270045

Phenotypes

Mouse phenotype:
embryonic lethality prior to organogenesis, decreased grip strength, preweaning lethality, complete penetrance

Subcellular localization

cytosol, nucleus

References: PMID:19481538

Functional category

  • Ciliary assembly/disassembly
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • ECM & connective tissue

Function

Fgf4 was required for the formation of cilia in Kupffer's vesicle, indicating that the role of Fgf4 in the LR patterning is quite distinct from that of Fgf8. Fgf4 plays a unique role in the LR patterning of visceral organs in zebrafish ( 19481538).