FGF8
fibroblast growth factor 8
Tier: Cilia-Associated Genes
- Ensembl:
- ENSG00000107831
- UniProt:
- P55075
- OMIM:
- 600483
- Synonyms:
- AIGF
Cilia effects upon perturbation of FGF8
- Cilia number / % ciliated:
- No effect
- Loss-of-function effect:
- No effect
- Overexpression effect:
- No effect
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.98) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- embryonic lethality prior to tooth bud stage, preweaning lethality, complete penetrance
- Human ciliopathy phenotype:
- hypogonadotropic hypogonadism 6 with or without anosmia
Ciliopathy associations
- Kallmann Syndrome
References: PMID:30445565, PMID:36138264, PMID:20362962, PMID:20389085, PMID:23368665
Subcellular localization
No ciliary localization reported (cilia-associated gene).
References: PMID:15932752, PMID:19242413
Functional category
- Ciliary assembly/disassembly
- Neurogenesis & migration
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
- Axon guidance & growth
- Transcription regulation
- Cilia length regulation
Function
Kupffer's vesicle is not only required for normal asymmetric development of the viscera, but also that in the absence of fgf8, this ciliated organ directs aberrant asymmetric development of the pharyngeal skeleton ( 15932752).Fgf8 and Fgf24 both signal through FGFR1 to maintain normal cilia length. Loss of both causes pronounced shortening(PMID: 19242413).