FGFR4

fibroblast growth factor receptor 4

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000160867
UniProt:
P22455
OMIM:
134935
Synonyms:
CD334, JTK2, TKF

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.14) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=871, lfc=0.52) PMID:30270045

Phenotypes

Mouse phenotype:
increased body length, hypospermia

Subcellular localization

lysosomes, nucleus

References: PMID:30564136

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Fgfr4 knockdown causes mispatterning of the left-right organizer (LRO) even before cilia on its surface initiate symmetry-breaking fluid flow, indicating a role in the earliest stages of LR development ( 30564136).