FGFR4

fibroblast growth factor receptor 4

Ensembl:
ENSG00000160867
UniProt:
P22455
OMIM:
134935
Synonyms:
CD334, JTK2, TKF

Cilia effects upon perturbation of FGFR4

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.14) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=871, lfc=0.52) PMID:30270045

Phenotypes

Mouse phenotype:
increased body length, hypospermia

Subcellular localization

cilia associated gene, lysosomes, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Fgfr4 knockdown causes mispatterning of the left-right organizer (LRO) even before cilia on its surface initiate symmetry-breaking fluid flow, indicating a role in the earliest stages of LR development ( 30564136).

Model organism evidence

Mus musculus (1 reference)

We show that FGFR1 and FGFR2, but not FGFR3 and FGFR4, localize to primary cilia of the developing mouse tissues and in vitro cells.

PMIDs: 40257378