FHOD1

formin homology 2 domain containing 1

Ensembl:
ENSG00000135723
UniProt:
Q9Y613
OMIM:
606881
Synonyms:
FHOS

Cilia effects upon perturbation of FHOD1

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.06) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
shortened rr interval, increased heart rate
Mouse ciliopathy phenotype:
increased heart weight

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

Formin homology 2 domain containing 1 (Fhod1) surrounded basal bodies in a donut-like fashion, occupying the space in between basal bodies and actin filaments(35440631)