FHOD3

Cilia effects upon perturbation of FHOD3

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.01) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

preweaning lethality, complete penetrance, abnormal hindbrain development, abnormal optic vesicle formation, pretal lethality prior to heart atrial septation, abnormal placenta vasculature, abnormal forebrain development, increased freezing behavior, abnormal neural tube morphology, abnormal placenta morphology, embryonic growth retardation, decreased exploration in new environment

Mouse ciliopathy phenotype:

abnormal neural tube closure, abnormal midbrain development, abnormal heart morphology

Subcellular localization

cilia

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Cardiac & muscle development

Function

Fhod3 localized to the anterior rootlet (Fig. 3c), and additio lly labeled posterior rootlets(35440631).