FHOD3

formin homology 2 domain containing 3

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000134775
UniProt:
Q2V2M9
OMIM:
609691
Synonyms:
FHOS2, FLJ22297, FLJ22717, KIAA1695

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.01) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, abnormal hindbrain development, abnormal optic vesicle formation, pretal lethality prior to heart atrial septation, abnormal placenta vasculature, abnormal forebrain development, increased freezing behavior, abnormal neural tube morphology, abnormal placenta morphology, embryonic growth retardation, decreased exploration in new environment

Subcellular localization

cilia

References: PMID:35440631

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cardiac & muscle development

Function

Fhod3 localized to the anterior rootlet (Fig. 3c), and additionally labeled posterior rootlets(35440631).