FIGNL1

fidgetin like 1

Ensembl:
ENSG00000132436
UniProt:
Q6PIW4

Cilia effects upon perturbation of FIGNL1

Cilia number / % ciliated:
Decreased cilia number(when overexpressed)
Loss-of-function effect:
Incrased cilia number
Overexpression effect:
Shorter

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.37) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-2.32) PMID:20393562

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Metabolism

Function

Overexpressed FIGL-1 markedly disturbs ciliogenesis and the centrosome structure. Endogenous FIGL-1 localizes to the centrosome in cells, preferentially to the mother centriole. Depletion of FIGL-1 enhances ciliogenesis and slows cilia disassembly(27384458).

Model organism evidence

Mus musculus (1 reference)

Indeed, overexpression of FIGL-1 interfered with ciliogenesis in cultured cells.

PMIDs: 27384458

Danio rerio (1 reference)

Indeed, overexpression of FIGL-1 interfered with ciliogenesis in cultured cells.

PMIDs: 27384458