FLOT1

flotillin 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000137312
UniProt:
O75955
OMIM:
606998

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, centrosome

References: PMID:18000879

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development

Function

FLOT1 have interactions of with BBS proteins and FLOT1 localize , at least partially, with g-tubulin within centrosomes (18000879). ,