FLOT2

flotillin 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000132589
OMIM:: 131560
Synonyms:: ECS-1, ECS1, ESA, ESA1, M17S1

Subcellular localization

cilia, Vesicles, Plasma membrane

Function

Transiently transfected GFP-OFD1 and flotillin-2-GFP localize to primary cilia of RCTE and MO6-G3 cells. PC1, PC2, EGFR, OFD1, and flotillin-2 are part of a multimeric protein complex in RCTE and MO6-G3 cells. Our demonstration that the flotillins localize to primary cilia of renal epithelia and odontoblasts and flotillin-2 interacts with the polycystins, EGFR and OFD1 in both cell types is extremely exciting for several reasons(25180832).

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