FLT4

fms related receptor tyrosine kinase 4

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000037280
UniProt:
P35916
OMIM:
136352
Synonyms:
PCL, VEGFR-3, VEGFR3

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:
congenital heart defects, multiple types, 7; renal cell carcinoma

Subcellular localization

cilia, nucleus

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

the vascular endothelial growth factor receptor 3 FLT4 localized at primary cilia