FMN1

formin 1

Ensembl:: ENSG00000248905
UniProt:: Q68DA7
OMIM:: 136535
Synonyms:: DKFZP686C2281, FLJ45135, FMN, LD, MGC125288

Cilia effects upon perturbation of FMN1

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-14.88) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia associated gene, nucleus

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Cell migration & adhesion

Function

RhoA works in concert with Fmn1 to control assembly of the specialized apical actin network in multiciliated epithelial cells ( 28089989). The formin group of actin nucleators such as DIAPH1-3, INF1, and **FMN1-2 are known to bind microtubules and influence their dynamics, leading to cross talk [with ciliary processes]. (33872598)

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