FN1

fibronectin 1

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000115414
UniProt:
P02751
OMIM:
135600
Synonyms:
CIG, FINC, GFND2, LETS, LNC-ABCA12-8, MSF

Cilia effects upon perturbation of FN1

Loss-of-function effect:
No effect

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

endosome, lysosomes

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Mutations in the FN1 gene cause Spondylometaphyseal Dysplasia (PMID: 4419008). The width of the node but not the length of the nodal cilia depends on FN (21466802)