FNBP1L

formin binding protein 1 like

Ensembl:: ENSG00000137942
UniProt:: Q5T0N5
OMIM:: 608848
Synonyms:: C1ORF39, FLJ20275, TOCA1

Cilia effects upon perturbation of FNBP1L

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: preweaning lethality, incomplete penetrance, increased lean body mass, increased bone mineral content

Subcellular localization

basal body

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Signaling (Hedgehog, GPCRs, ion channels)

Function

TOCA1. Target of miR-129-3p in ciliation-related actin dy mics, which induces ciliation in proliferating cells and also promoted cilia elongation (22684256). Binds to Cdc42, leading to actin rearrangements, which are thought to be involved in processes such as endocytosis (27129201).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.