FOS

Fos proto-oncogene, AP-1 transcription factor subunit

Ensembl:
ENSG00000170345
UniProt:
P01100
OMIM:
164810
Synonyms:
AP-1, C-FOS

Cilia effects upon perturbation of FOS

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=315, lfc=0.68) PMID:30270045

Phenotypes

Mouse phenotype:
no spontaneous movement, preweaning lethality, incomplete penetrance, decreased lean body mass, hemorrhage, increased total body fat amount, decreased exploration in new environment
Mouse ciliopathy phenotype:
abnormal facial morphology

Subcellular localization

cilia associated gene, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

H2S induced oxidative stress leads to tracheal inflammation through FOS/IL8 sig ling, leading to excessive mucus secretion and absence of cilia ( 30684762).

Model organism evidence

Mus musculus (2 references)

Primary Cilia Mediate Stress Vulnerability and Exercise-Induced Antidepressant Adaptation: Evidence for Ventral Hippocampal Astrocytic Ciliary Remodeling.

Hypoxia-Inducible Factor-2alpha Affects the MEK/ERK Signaling Pathway via Primary Cilia in Connection with the Intraflagellar Transport Protein 88 Homolog.

PMIDs: 41956699, 37074220