FOXA1

forkhead box A1

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000129514
UniProt:
P55317
OMIM:
602294
Synonyms:
HNF3A

Cilia effects upon perturbation of FOXA1

Loss-of-function effect:
Impaired ciliogenesis

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.27) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

nucleus

References: PMID:36509813

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • ECM & connective tissue
  • Transcription regulation

Function

FOXA1 is a transcriptional activator of Odf2, Foxa1 knockdown caused a decrease in ODF2 and CP110 proteins. Knockdown of FOXA1 affected primary cilia formation ( 36509813). Knockdown of FOXA1 affected primary cilia formation. FOXA1 regulates primary ciliation by transcriptional activation of ciliary genes. (36509813)