FOXA2

forkhead box A2

Ensembl:
ENSG00000125798
UniProt:
Q9Y261
OMIM:
600288
Synonyms:
HNF3B

Cilia effects upon perturbation of FOXA2

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.85) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Transcription regulation

Function

Foxa1, Foxa2, and Foxj1 were dy mically regulated after injury and restoration of the bronchiolar epithelium, the highest levels of expression being observed in ciliated cells and their derivatives early in the repair process ( 16239640).

Model organism evidence

C. elegans (1 reference)

Ciliome gene mutations underlie a group of pleiotropic genetic diseases known as ciliopathies.

PMIDs: 37449480

Mus musculus (2 references)

We observed cells expressing FOXJ1 in the central region in all cases, which co-expressed SOX2 and PAX6 as well as RFX2 and ARL13B, two proteins involved in ciliogenesis and cilia-mediated sonic hedgehog signaling, respectively.

BACKGROUND: Rfx winged-helix transcription factors, best known as key regulators of core ciliogenesis, also play ciliogenesis-independent roles during neural development.

PMIDs: 37329342, 29243319

Danio rerio (1 reference)

BACKGROUND: Rfx winged-helix transcription factors, best known as key regulators of core ciliogenesis, also play ciliogenesis-independent roles during neural development.

PMIDs: 29243319