FOXC2

forkhead box C2

Ensembl:
ENSG00000176692
UniProt:
Q99958
OMIM:
602402
Synonyms:
FKHL14, MFH-1

Cilia effects upon perturbation of FOXC2

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.97) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.64) PMID:29459680

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • ECM & connective tissue
  • Transcription regulation

Function

The deletion of Ift46 in NCCs led to reduced Shh sig l activity in the periocular mesenchyme, sustained expression of key transcription factors Foxc1, Foxc2 and Pitx2, along with persistent cell proliferation ( 38517430).

Model organism evidence

Mus musculus (1 reference)

Primary Cilium in Neural Crest Cells Crucial for Anterior Segment Development and Corneal Avascularity.

PMIDs: 38517430