FOXC2

forkhead box C2

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000176692
UniProt:
Q99958
OMIM:
602402
Synonyms:
FKHL14, MFH-1

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.97) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.64) PMID:29459680

Subcellular localization

nucleus

References: PMID:38517430

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • ECM & connective tissue
  • Transcription regulation

Function

The deletion of Ift46 in NCCs led to reduced Shh signal activity in the periocular mesenchyme, sustained expression of key transcription factors Foxc1, Foxc2 and Pitx2, along with persistent cell proliferation ( 38517430).