FOXF1

forkhead box F1

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000103241
UniProt:
Q12946
OMIM:
601089
Synonyms:
FKHL5, FREAC1

Cilia effects upon perturbation of FOXF1

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

nucleus

References: PMID:30950350

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Cardiac & muscle development

Function

FoxF1 is required for ciliogenesis in vitro and in vivo and for the proper localization of Shh signaling components in cilium ( 30950350). FoxF1 knockdown decreased the cilium length in NIH/3T3 cells. FoxF1 deficiency significantly reduced the number of ciliated cells and disrupted the distribution of SHH pathway components in cilia ((30950350)