FOXG1

forkhead box G1

Ensembl:
ENSG00000176165
UniProt:
P55316
OMIM:
164874
Synonyms:
BF1, FKH2, FKHL1, FKHL2, FKHL3

Cilia effects upon perturbation of FOXG1

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Longer cilia
Overexpression effect:
Shorter

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.63) PMID:29459680

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Neurogenesis & migration
  • Cell migration & adhesion
  • Axon guidance & growth
  • Transcription regulation

Function

FOXG1 syndrome neural progenitor cells have increased frequency of primary cilia. Engineered FOXG1 dose correlates with proliferation and frequency of primary cilia ( 35148845). Inducible FOXG1 expression reduces primary cilia and increases proliferation in neural progenitor cells. Loss of FOXG1 leads to increased primary cilia in forebrain neural progenitor cells (35148845)

Model organism evidence

C. elegans (1 reference)

Distinct IFT mechanisms contribute to the generation of ciliary structural diversity in C.

PMIDs: 17510633