FOXG1
forkhead box G1
Tier: Cilia-Associated Genes
- Ensembl:
- ENSG00000176165
- UniProt:
- P55316
- OMIM:
- 164874
- Synonyms:
- BF1, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, FOXG1A, FOXG1B, FOXG1C, HBF-3, HFK1, HFK2, HFK3, QIN
Cilia effects upon perturbation of FOXG1
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Longer cilia
- Overexpression effect:
- Shorter
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.63) PMID:29459680
Subcellular localization
nucleus
References: PMID:35148845
Functional category
- Ciliary assembly/disassembly
- Neurogenesis & migration
- Cell migration & adhesion
- Axon guidance & growth
- Transcription regulation
Function
FOXG1 syndrome neural progenitor cells have increased frequency of primary cilia. Engineered FOXG1 dose correlates with proliferation and frequency of primary cilia ( 35148845). Inducible FOXG1 expression reduces primary cilia and increases proliferation in neural progenitor cells. Loss of FOXG1 leads to increased primary cilia in forebrain neural progenitor cells (35148845)