FOXI1

Cilia effects upon perturbation of FOXI1

Cilia number / % ciliated:

Decreased cilia number

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.06) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:

autosomal recessive nonsyndromic hearing loss 4

Subcellular localization

cilia, nucleus

Functional category

• Ciliary assembly/disassembly

Function

FOXI1 KO led to mature hiPSC-AEC epithelia without ionocytes with reduced capacity to produce ciliated cells(38664797). Functional assays reveal that FOXI1 KO leads to decreased numbers of ciliated cells in hiPSC-AECs.