FOXO1

Cilia effects upon perturbation of FOXO1

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

increased aggression, increased mean corpuscular volume, decreased erythrocyte cell number, hyperactivity, preweaning lethality, complete penetrance, embryonic lethality prior to tooth bud stage

Mouse ciliopathy phenotype:

increased circulating bilirubin level

Subcellular localization

cilia associated gene, cytosol, nucleus

Functional category

• Ciliary assembly/disassembly
• T cell biology
• Signaling (Hedgehog, GPCRs, ion channels)
• Cardiac & muscle development
• Transcription regulation

Function

Primary cilium modulates human decidualization through PTEN-PI3K-AKT-FOXO1 sig ling ( 36555215). Those values were reduced by more than 50% … While deletion of Foxo1 completely blocked the effect of AGEs stimulation on primary cilia number and length (37591875)

Model organism evidence