FSCB
fibrous sheath CABYR binding protein
- Ensembl:
- ENSG00000189139
- UniProt:
- Q5H9T9
- OMIM:
- 611779
- Synonyms:
- C14ORF155, DKFZP434F1017
Cilia effects upon perturbation of FSCB
Ciliogenesis screen results (1 screen)
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- hyperactivity, decreased total reti thickness, abnormal reti inner nuclear layer morphology, increased vertical activity, abnormal reti outer nuclear layer morphology
Subcellular localization
flagella
Functional category
- Reproduction & sperm
Function
FSCB serum recognized with an intense sig l the entire length of the principal piece of both non-fixed, air dried and methanol-fixed non-capacitated sperm by indirect immunofluorescence microscopy (17855365).
Model organism evidence
Mus musculus (2 references)
The fibrous sheath (FS) is a flagellar cytoskeletal structure unique to sperm that surrounds the outer dense fibers and axoneme.
We report characterization of a novel testis- and sperm-specific protein, FSCB (fibrous sheath CABYR binding), that is expressed post-meiotically and localized in mouse sperm flagella.