FSD1

fibronectin type III and SPRY domain containing 1

Ensembl:: ENSG00000105255
UniProt:: Q9BTV5
OMIM:: 609828
Synonyms:: MGC3213, MIR1

Cilia effects upon perturbation of FSD1

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.60) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, nucleus

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Transition zone

Function

Anchors asters to interphase centrosomes by directly binding to mother centriole, and controls transition zone assembly during ciliogenesis. FSD1 knockdown causes defective ciliogenesis and affects embryonic development in vertebrates (30538248)

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