FUT8

fucosyltransferase 8

Ensembl:
ENSG00000033170
UniProt:
Q9BYC5
OMIM:
602589

Cilia effects upon perturbation of FUT8

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transition zone

Function

FUT8 interacts with transmembrane protein 67 (TMEM67), a transition zone component closely linked to ciliopathies, and catalyzes its core fucosylation(PMID: 40728580). Core fucosylation by FUT8 maintains TMEM67 stability and promotes ciliogenesis, FUT8 deficiency leads to defective cilia formation characterized by reduced ciliary length and fewer ciliated cells. (40728580)

Model organism evidence

Mus musculus (1 reference)

FUT8-mediated core fucosylation stabilizes TMEM67 to promote ciliogenesis.

PMIDs: 40728580