FUT8

fucosyltransferase 8

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000033170
UniProt:
Q9BYC5
OMIM:
602589

Cilia effects upon perturbation of FUT8

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:40728580

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transition zone

Function

FUT8 interacts with transmembrane protein 67 (TMEM67), a transition zone component closely linked to ciliopathies, and catalyzes its core fucosylation(PMID: 40728580). Core fucosylation by FUT8 maintains TMEM67 stability and promotes ciliogenesis, FUT8 deficiency leads to defective cilia formation characterized by reduced ciliary length and fewer ciliated cells. (40728580)