FZD2

frizzled class receptor 2

Ensembl:
ENSG00000180340
UniProt:
Q14332
OMIM:
600667

Cilia effects upon perturbation of FZD2

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.73) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, hyperactivity, embryonic lethality prior to tooth bud stage, embryonic lethality prior to organogenesis

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

FZD2 has localized in basal body.