FZD3

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.50) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

decreased bone mineral content, decreased grip strength, increased total body fat amount, impaired glucose tolerance, preweaning lethality, incomplete penetrance

Subcellular localization

cilia

References: PMID:25124458, PMID:23593172

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Neurogenesis & migration
• Signaling (Hedgehog, GPCRs, ion channels)
• Axon guidance & growth

Function

Planar cell polarity (PCP) proteins are known to organize microtubule polarization, which establishes the planar polarity of cells (25124458). During Wnt signaling, a Wnt ligand binds to the seven-pass transmembrane receptor Fzd, which then recruits a scaffold protein Dvl that induces downstream signaling (17884187). Fzd-3 localized at primary cilia of both mouse embryonic fibroblasts (MEFs) , indicating that Wnt signaling may be regulated directly by activation of receptors in the cilium, and that ciliary targeting of Fzd-3 is independent of Inversin(23593172).