FZD3
frizzled class receptor 3
- Ensembl:
- ENSG00000104290
- UniProt:
- Q9NPG1
- OMIM:
- 606143
- Synonyms:
- FZ-3
Cilia effects upon perturbation of FZD3
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.50) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- decreased bone mineral content, decreased grip strength, increased total body fat amount, impaired glucose tolerance, preweaning lethality, incomplete penetrance
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Neurogenesis & migration
- Signaling (Hedgehog, GPCRs, ion channels)
- Axon guidance & growth
Function
Pla r cell polarity (PCP) proteins are known to organize microtubule polarization, which establishes the pla r polarity of cells (25124458). During Wnt sig ling, a Wnt ligand binds to the seven-pass transmembrane receptor Fzd, which then recruits a scaffold protein Dvl that induces downstream sig ling (17884187). Fzd-3 localized at primary cilia of both mouse embryonic fibroblasts (MEFs) , indicating that Wnt sig ling may be regulated directly by activation of receptors in the cilium, and that ciliary targeting of Fzd-3 is independent of Inversin(23593172).
Model organism evidence
We demonstrated that the progressive posterior polarization of the primary cilia of floorplate cells requires not only Vangl2 but also Fzd3a.
PMIDs: 31029691
During the past decade, evidence has accumulated for a key role of CELSR1 in epithelial planar cell polarity (PCP), and for CELSR2 and CELSR3 in ciliogenesis and neural development, especially neuron migration and axon guidance in the central, peripheral and enteric nervous systems.
A role for planar cell polarity (PCP) signaling in the orientation of cilia (rotational polarity) and ciliogenesis is established.