FZD4

frizzled class receptor 4

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000174804
UniProt:
Q9ULV1
OMIM:
604579
Synonyms:
CD344, EVR1

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.92) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=681, lfc=0.69) PMID:30270045

Phenotypes

Mouse phenotype:
edema

Subcellular localization

cilia

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

FZD4 has localized in primary cilia. Localizes to primary cilium in human cells (according to HPA). However, spatial proteomics atlas classifies it among proteins with no cilia annotation. (41005307)