FZD6
frizzled class receptor 6
- Ensembl:
- ENSG00000164930
- UniProt:
- O60353
- OMIM:
- 603409
- Synonyms:
- HFZ6
Cilia effects upon perturbation of FZD6
Ciliogenesis screen results (4 screens)
- Kim2016: No effect
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.44, ciliated=19.0%) PMID:26595381
Subcellular localization
basal body
Functional category
- Ciliary assembly/disassembly
- Signaling (Hedgehog, GPCRs, ion channels)
- Transcription regulation
Function
FZD6 has localized in basal body. Cytoplasmic Dynein Functions in Planar Polarization of Basal Bodies within Ciliated Cells (32535020)
Model organism evidence
Mus musculus (2 references)
Spag6 encodes an axoneme central apparatus protein that is required for normal flagellar and cilia motility.
During the past decade, evidence has accumulated for a key role of CELSR1 in epithelial planar cell polarity (PCP), and for CELSR2 and CELSR3 in ciliogenesis and neural development, especially neuron migration and axon guidance in the central, peripheral and enteric nervous systems.