FZD6

frizzled class receptor 6

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000164930
UniProt:
O60353
OMIM:
603409
Synonyms:
HFZ6

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-2.44, ciliated=19.0%) PMID:26595381

Subcellular localization

basal body, cilia

References: PMID:41005307, PMID:32535020

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

FZD6 has localized in basal body. Cytoplasmic Dynein Functions in Planar Polarization of Basal Bodies within Ciliated Cells (32535020)