FZD8

frizzled class receptor 8

Ensembl:
ENSG00000177283
UniProt:
Q9H461
OMIM:
606146
Synonyms:
FZ-8

Cilia effects upon perturbation of FZD8

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-7.19) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased heart left ventricle size, increased cardiac muscle contractility, abnormal eye anterior chamber depth, decreased circulating bilirubin level
Mouse ciliopathy phenotype:
thick ventricular wall

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • T cell biology
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

FZD8 has localized in primary cilia.