G3BP2
G3BP stress granule assembly factor 2
- Ensembl:
- ENSG00000138757
- UniProt:
- Q9UN86
- OMIM:
- 620020
- Synonyms:
- KIAA0660
Cilia effects upon perturbation of G3BP2
- Cilia number / % ciliated:
- No effect
- Loss-of-function effect:
- Longer cilia
- Overexpression effect:
- Unknown
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- preweaning lethality, complete penetrance
Subcellular localization
cilia associated gene
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Viral interactions
- Signaling (Hedgehog, GPCRs, ion channels)
- Transcription regulation
Function
G3BP1 and G3BP2 do not affect cilium formation but regulate cilium length. In addition, the extent of cilium elongation in G3BP dKO cells was greater than that in G3BP1 KO or G3BP2 KO cells , suggesting that both G3BP1 and G3BP2 may regulate cilium elongation in parallel(38088586).