GABBR1

gamma-aminobutyric acid type B receptor subunit 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000232632
UniProt:: Q9UBS5
OMIM:: 603540
Synonyms:: GPRC3A, HGB1A

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.39) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, ciliary tip

References: PMID:41005307

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

GABBR1 has localized in basal body. GABAB1 receptors are strongly enriched at the base of the cilium, but are mobilized to more distal locations upon agonist binding (36350286)

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