GALNT11

polypeptide N-acetylgalactosaminyltransferase 11

Ensembl:
ENSG00000178234
UniProt:
Q8NCW6
OMIM:
615130
Synonyms:
GALNAC-T11

Cilia effects upon perturbation of GALNT11

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.36) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.68) PMID:41160700

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly

Function

Candidate disease gene in heterotaxy. Modifies Notch to establish an essential balance between motile and immotile cilia at the left-right organiser, necessary to determine laterality. Galnt11 (or notch1) depletion increases the ratio of motile cilia at the expense of immotile cilia (24226769) Manipulations of Galnt11 altered the density of ciliated epidermal cells (