GAP43

growth associated protein 43

Ensembl:
ENSG00000172020
UniProt:
P17677
OMIM:
162060
Synonyms:
B-50, GAP-43, PP46

Cilia effects upon perturbation of GAP43

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Axon guidance & growth

Function

The B50/GAP43 protein is present throughout the receptor neuron, including the perikaryon, sy ptic projections of these neurons in the olfactory bulb, the proximal portion of the olfactory cilia, the dendritic process, and the axon(2918383).